Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).

@article{Loon2013AlkyladenineDG,
  title={Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).},
  author={Barbara van Loon and Leona D. Samson},
  journal={DNA repair},
  year={2013},
  volume={12 3},
  pages={
          177-87
        }
}
  • Barbara van Loon, Leona D. Samson
  • Published in DNA repair 2013
  • Chemistry, Biology, Medicine
  • Due to a harsh environment mitochondrial genomes accumulate high levels of DNA damage, in particular oxidation, hydrolytic deamination, and alkylation adducts. While repair of alkylated bases in nuclear DNA has been explored in detail, much less is known about the repair of DNA alkylation damage in mitochondria. Alkyladenine DNA glycosylase (AAG) recognizes and removes numerous alkylated bases, but to date AAG has only been detected in the nucleus, even though mammalian mitochondria are known… CONTINUE READING

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