Alkyl phosphocholines: Toxicity and anticancer properties

@article{Muschiol2006AlkylPT,
  title={Alkyl phosphocholines: Toxicity and anticancer properties},
  author={C. Muschiol and M. Berger and B. Schuler and H. R. Scherf and F. Garzon and W. Zeller and C. Unger and H. Eibl and D. Schm{\"a}hl},
  journal={Lipids},
  year={2006},
  volume={22},
  pages={930-934}
}
The study reports on the investigation of acute and subacute toxicity and on antineoplastic activity of hexadecylphosphocholine (HPC), the first compound of a new class of antineoplastic chemotherapeutics. In rats, the LD50 of HPC was 606 μmol/kg; the maximum tolerable dose over four weeks was 39 μmol/kg. Symptoms of toxicity were enteritis, spider cell activation in the liver, hemosiderosis in the spleen and reversible transaminase increase. The best therapeutic effect was observed on… Expand
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References

SHOWING 1-9 OF 9 REFERENCES
Chemotherapy studies in autochthonous rat tumors intestinal cancer
  • 15
Angewandte Statistik {Sachs, L., ed
  • December 29,
  • 1986
Advances in the Chemotherapy of Gastrointestinal Cancer {Klein, H.O., ed
  • 1984
Preclinical drug development: rationale and methods.
  • 92