Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells

@article{Hosono2008AlkenylGI,
  title={Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells},
  author={Takashi Hosono and Tomomi Hosono-Fukao and Kahoru Inada and Rie Tanaka and Haruhisa Yamada and Yuji Iitsuka and Taiichiro Seki and Isao Hasegawa and Toyohiko Ariga},
  journal={Carcinogenesis},
  year={2008},
  volume={29},
  pages={1400 - 1406}
}
Alk(en)yl trisulfides (R-SSS-R') are organosulfur compounds produced by crushed garlic and other Allium vegetables. We found that these compounds exhibit potent anticancer effects through the reaction with microtubules, causing cell cycle arrest. Nine alk(en)yl trisulfides including dimethyl trisulfide, diethyl trisulfide, dipropyl trisulfide (DPTS), dibutyl trisulfide, dipentyl trisulfide, diallyl trisulfide (DATS), dibutenyl trisulfide, dipentenyl trisulfide and allyl methyl trisulfide were… CONTINUE READING