Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.

@article{Nay2012Alkbh2PA,
  title={Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.},
  author={Stephanie L. Nay and Dong-Hyun Lee and Steven E. Bates and T. R. O'Connor},
  journal={DNA repair},
  year={2012},
  volume={11 5},
  pages={502-10}
}
Alkylating agents modify DNA and RNA forming adducts that disrupt replication and transcription, trigger cell cycle checkpoints and/or initiate apoptosis. If left unrepaired, some of the damage can be cytotoxic and/or mutagenic. In Escherichia coli, the alkylation repair protein B (AlkB) provides one form of resistance to alkylating agents by eliminating mainly 1-methyladenine and 3-methylcytosine, thereby increasing survival and preventing mutation. To examine the biological role of the… CONTINUE READING