Alkaloids of Aconitum coreanum. X. Curare-Like Activity-Structure Relationship

Abstract

The biological activity of 11 alkaloids isolated from Aconitum coreanum was studied. The compounds exhibit myorelaxant activity. Isoatisine and coryphine, which contain oxazolidine rings, are the most active. N-Oxides of 2-isobutyryl-14-hydroxyhetisine and 2-isobutyryl-13-acetyl-14-hydroxyhetisine are least active. 
DOI: 10.1023/A:1015742001422

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