Alkaloids of Aconitum coreanum. X. Curare-Like Activity-Structure Relationship


The biological activity of 11 alkaloids isolated from Aconitum coreanum was studied. The compounds exhibit myorelaxant activity. Isoatisine and coryphine, which contain oxazolidine rings, are the most active. N-Oxides of 2-isobutyryl-14-hydroxyhetisine and 2-isobutyryl-13-acetyl-14-hydroxyhetisine are least active. 
DOI: 10.1023/A:1015742001422


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