Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity.

  title={Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity.},
  author={Bao-Bao Shi and Jing Chen and Mei‐Fen Bao and Ying Zeng and Xiang-Hai Cai},
Continued interest in bioactive alkaloids led to the isolation of four undescribed alkaloids along with 74 known ones from the aerial parts of Tabernaemontana bufalina Lour. The structures of the yet undescribed alkaloids were elucidated based on NMR, IR, UV, MS and CD spectroscopic data and X-ray crystal diffraction and, according to the plant source, named as taberhaines A-D (1-4). The known compounds comprised of 66 monoterpenoid indole, three carboline and five isoquinoline alkaloids. Among… 
Isolation and structure elucidation of tabercetimines A-D, four new quaternary monoterpenoid indole alkaloids from Tabernaemontana divaricata
Abstract Tabercetimines A-D, four new quaternary monoterpenoid indole alkaloids with rare skeleton characterized by a quinuclidine moiety were isolated from the stems of Tabernaemontana divaricata.
An Aspidosperma-type alkaloid dimer from Tabernaemontana bovina as a candidate for the inhibition of microglial activation
Twelve undescribed bisindole alkaloids, tabernaemontines A–L, were simultaneously isolated from the leaves of Tabernaemontana bovina and their structures were elucidated by spectroscopic methods. All
Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease.
One undescribed indole alkaloid together with twenty-two known compounds have been isolated from aerial parts of Vinca minor L. (Apocynaceae) by a combination of MS, HRMS, 1D, and 2D NMR techniques, and by comparison with literature data.
Metabolic profiling of monoterpenoid indole alkaloids from Tabernaemontana catharinensis (A. DC) latex by GC-MS
Abstract Latex from Tabernaemontana catharinensis contains synthesized bioactive compounds known as monoterpenoid indole alkaloids (MIAs). Such compounds have several biological activities, including
Recent Advances in the Synthesis of β-Carboline Alkaloids
This review describes the recent developments in the synthesis of β-carboline alkaloids and closely related derivatives through selected examples from the last 5 years, focusing on the key steps with improved procedures and synthetic approaches.
Monoterpenoid indole alkaloids from Kopsia hainanensis Tsiang
Compounds 1–2, 4–5, 7, and 10–17 are herein reported for the first time from this plant, while the compounds 1, 2, 7 and 12–17 have not been previously recorded in the Kopsia genus.
8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities
In this review, the nomenclature, chemical structures, botanical sources, pharmacological activities, and synthetic approaches of this set of dimeric alkaloids are presented.
Novel 1,2,3-triazole compounds: Synthesis, In vitro xanthine oxidase inhibitory activity, and molecular docking studies
Abstract In this study, novel 1,2,3-triazole compounds containing carbasugar frameworks (5 and 6) were synthesized by the copper-catalyzed azide-alkyne cycloaddition reactions and their in vitro
A Divergent Enantioselective Total Synthesis of Post-Iboga Indole Alkaloids.
Divergent enantioselective total syntheses of five naturally occurring post-iboga indole alkaloids, dippinine B and C, and two analogues 11-demethoxydippinine A and D, were presented for the first time.
Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species
A core group of 10 scientifically lesser-known botanical species that may potentially be developed into more widely used topical preparations for photodynamic treatment of infected wounds are determined, which may contribute to developing a more evidence-based use of herbal medicines.


Cytotoxic indole alkaloids from Tabernaemontana officinalis.
Alkaloids 1 and 2 are voaphylline-vobasinyl type bisindole alkaloids, a structural type previously unknown, while 3-6 exhibited cytotoxicity against three human cancer cell lines HeLa, MCF-7, and SW480 with IC50 values ranging from 1.42 to 11.35 μM.
Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata.
The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine,
Five new iboga alkaloids from Tabernaemontana corymbosa.
  • T. Kam, K. Sim
  • Chemistry, Medicine
    Journal of natural products
  • 2002
Five new indole alkaloids of the ibogan type were obtained from the leaf and stem-bark extract of the Malayan species Tabernaemontana corymbosa, and the structures were determined using NMR and MS analysis and comparison with known related compounds.
Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity
Compounds ibogamine, 3-oxo-coronaridine and 12-methoxy-4-methylvoachalotine demonstrated effective cytotoxicity towards SKBR-3 breast adenocarcinoma and C-8161 human melanoma tumor cell lines.
Biologically active indole alkaloids from Kopsia arborea.
Nine new indole alkaloids, rhazinoline, 19(S)-methoxytubotaiwine, in addition to several recently reported novel indoles and 34 other known ones, were obtained from the stem-bark extract of the Malayan Kopsia arborea using NMR and MS analysis.
Novel monoterpenoid indole alkaloids from Melodinus yunnanensis
Abstract Five monoterpenoid indole alkaloids, namely meloyines A-B ( 1 – 2 ), meloyines II-III ( 3 – 4 ), and 10- O -glucosyl-scandine ( 5 ) together with thirty-four known alkaloids were isolated
New alkaloids from Tabernaemontana divaricata
Abstract A re-investigation of the root bark of Tabernaemontana divaricata resulted in the isolation of 18 compounds, viz. α-amyrin acetate, lupeol acetate, α-amyrin, lupeol, cycloartenol,
Anticancer indole alkaloids of Ervatamia heyneana
Abstract The wood and stem bark of Ervatamia heyneana (Apocynaceae) yielded 14 indole alkaloids and 3 triterpenoids. Six of these isolates, camptothecin (2), 9-methoxycamptothecin (3), coronaridine
Biologically Active Ibogan and Vallesamine Derivatives from Tabernaemontana divaricata
Six new indole alkaloids were obtained from the stem‐bark extract of the Malayan Tabernaemontana divaricata and showed appreciable cytotoxicity towards the KB human oral epidermoid carcinoma cell‐line.
Studies on Plants containing Indole Alkaloids. VI. Minor Bases of Uncaria rhynchophylla MIQ.
Two minor alkaloids were newly isolated from Uncaria rhynchophylla MIQ., and their structures elucidated as geissoschizine methyl ether (a new compound) and akuammigine, respectively. The Cotton