Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.

@article{Peng2013AlkaloidsFT,
  title={Alkaloids from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013.},
  author={Jiang-Hua Peng and Xiao-yong Zhang and Zheng-chao Tu and Xin-ya Xu and S. Qi},
  journal={Journal of natural products},
  year={2013},
  volume={76 5},
  pages={
          983-7
        }
}
Two new benzodiazepine alkaloids, circumdatins K and L (1, 2), two new prenylated indole alkaloids, 5-chlorosclerotiamide (3) and 10-epi-sclerotiamide (4), and one novel amide, aspergilliamide B (5), together with six known alkaloids were isolated from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013. Their structures were elucidated by extensive spectroscopic analysis. All of the compounds were tested for cytotoxicity toward human carcinoma A549, HL-60, K562, and MCF-7 cell… Expand
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References

SHOWING 1-10 OF 15 REFERENCES
Notoamides F-K, prenylated indole alkaloids isolated from a marine-derived Aspergillus sp.
Six new prenylated indole alkaloids, named notoamides F-K (8-13), were isolated from a marine-derived Aspergillus sp. Their structures, including absolute configurations, were elucidated byExpand
Notoamides A–D: Prenylated Indole Alkaloids Isolated from a Marine‐Derived Fungus, Aspergillus sp.
Six new prenylated indole alkaloids, named notoamides F−K (8−13), were isolated from a marine-derived Aspergillus sp. Their structures, including absolute configurations, were elucidated byExpand
Circumdatin I, a New Ultraviolet-A Protecting Benzodiazepine Alkaloid from a Marine Isolate of the Fungus Exophiala
TLDR
A new ultraviolet-A (UV-A) protecting benzodiazepine alkaloids have been isolated from the mycelium of a marine-derived fungus of the genus Exophiala and the structures of the three circumdatins were assigned on the basis of physicochemical evidence. Expand
Circumdatins D, E, and F: further fungal benzodiazepine analogues from aspergillus ochraceus
Three new benzodiazepine alkaloids belonging to the circumdatin series have been isolated as minor constituents of culture extracts of a terrestrial strain of the fungus Aspergillus ochraceus. TheirExpand
Structure revision of circumdatins A and B, benzodiazepine alkaloids produced by marine fungus Aspergillus ostianus, by X-ray crystallography.
The structures of circumdatins A and B, pentacyclic alkaloids produced by Aspergillus ostianus, were revised from the previously reported betaine structures to unique oxepin ones by X-rayExpand
New mycotoxins from marine-derived fungus Aspergillus sp. SCSGAF0093.
TLDR
Nine mycotoxins including zirconium complex obtained from nature and ochratoxins isolated from marine environment were isolated from the fermentation broth of marine gorgonian derived fungus Aspergillus sp. Expand
Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum.
TLDR
Sclerotiamide causes significant mortality and unusual physiological effects in dietary assays against the corn earworm Helicoverpa zea. Expand
Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus.
TLDR
The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication, leading to the isolation of the known compound mellein as the active component of the extract. Expand
Sclerotigenin: A new antiinsectan benzodiazepine from the sclerotia of penicillium sclerotigenum
TLDR
A new benzodiazepine, sclerotigenin, was isolated from organic extracts of the sclerOTia of Penicillium sclerotsia along with two known griseofulvin analogues and is responsible for most of the antiinsectan activity of the extract against the crop pest Helicoverpa zea. Expand
Total syntheses of the benzodiazepine alkaloids circumdatin F and circumdatin C.
Total syntheses of circumdatin F and circumdatin C, which both possess a 3H-quinazolin-4-one as well as a 1,4-benzodiazepin-5-one moiety, are described. A tripeptide derivative was synthesized as aExpand
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