Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubes.

  title={Alkaloids from Coptis chinensis root promote glucose uptake in C2C12 myotubes.},
  author={Te-Chun Yang and Hsin-Fan Chao and Li-Shian Shi and Tsu-Chung Chang and H Lin and Wen-liang Chang},
The root of Coptis chinensis Franch. (COCH) is regularly used for medicinal purposes, and has been prescribed alone or in combination with other traditional herbs for the treatment of diabetes. To investigate the effects of COCH on glucose utilization by skeletal muscles, we prepared an ethanol extract of COCH root (COCH-Et) partitioned with dichloromethane, n-butanol, and water and tested its effects on glucose uptake in differentiated C2C12 myotubes. We found that dichloromethane and n… CONTINUE READING
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