Alkaloids as aldose reductase inhibitors, with special reference to berberine.

@article{Gupta2014AlkaloidsAA,
  title={Alkaloids as aldose reductase inhibitors, with special reference to berberine.},
  author={Sakshi Gupta and Nirmal Singh and Amteshwar Singh Jaggi},
  journal={Journal of alternative and complementary medicine},
  year={2014},
  volume={20 3},
  pages={195-205}
}
Aldose reductase is the rate-limiting enzyme of the polyol pathway that leads to conversion of glucose to sorbitol. Its increased activity, which results in abnormal activation of the polyol pathway, is implicated in the development of long-term complications of diabetes mellitus. Different plant species and their active components have shown potent in… CONTINUE READING