Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease

@article{Konrath2013AlkaloidsAA,
  title={Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease},
  author={E. Konrath and C. S. Passos and L. Klein-J{\'u}nior and A. Henriques},
  journal={Journal of Pharmacy and Pharmacology},
  year={2013},
  volume={65}
}
The inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is currently the main pharmacological strategy available for Alzheimer's disease (AD). In this sense, many alkaloids isolated from natural sources, such as physostigmine, have been long recognized as acetyl‐ and butyrylcholinesterase (BChE) inhibitors. Since the approval of galantamine for the treatment of AD patients, the search for new anticholinesterase alkaloids has escalated, leading to… Expand
Plant alkaloids as drug leads for Alzheimer's disease
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