Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids.

Abstract

The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6''-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9). The alkaloids quindolinone (6) and cryptolepine salt (9) showed vasorelaxant activity in rodent isolated mesenteric arteries.

DOI: 10.3390/molecules22010094

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@article{Chaves2017AlkaloidsAP, title={Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids.}, author={Otemberg Souza Chaves and Yanna Carolina Ferreira Teles and Matheus Morais de Oliveira Monteiro and Le{\^o}nidas das Graças Mendes Junior and Maria de F{\'a}tima Agra and Valdir de Andrade Braga and T{\^a}nia Maria Sarmento Silva and Maria de F{\'a}tima Vanderlei de Souza}, journal={Molecules}, year={2017}, volume={22 1} }