Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells.

@article{Nakamura2013AlkaloidCF,
  title={Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells.},
  author={Seikou Nakamura and Souichi Nakashima and Genzoh Tanabe and Yoshimi Oda and Nami Yokota and Katsuyoshi Fujimoto and Takahiro Matsumoto and Rika Sakuma and Tomoe Ohta and Keiko Ogawa and Shino Nishida and Hisako Miki and Hisashi Matsuda and Osamu Muraoka and Masayuki Yoshikawa},
  journal={Bioorganic \& medicinal chemistry},
  year={2013},
  volume={21 3},
  pages={
          779-87
        }
}
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Lignan dicarboxylates and terpenoids from the flower buds of Cananga odorata and their inhibitory effects on melanogenesis.
TLDR
These isolated terpenoid derivatives may be promising therapeutic agents for the treatment of several skin disorders after showing an inhibitory effect on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.
Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity
A quantitative analytical method for five aporphine alkaloids, nuciferine (1), nornuciferine (2), N-methylasimilobine (3), asimilobine (4), and pronuciferine (5), and five benzylisoquinoline…
Quantitative Determination of Principal Aporphine and Benzylisoquinoline Alkaloids Due to Blooming State in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Hyaluronidase Inhibitory Activity
Using a recently developed analytical protocol, distributions of 5 aporphine alkaloids, nuciferine (1), nornuciferine (2), N-methylasimilobine (3), asimilobine (4), and pronuciferine (5), and 5…
Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells.
Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna).
Purification and Characterization of Aporphine Alkaloids from Leaves of Nelumbo nucifera Gaertn and Their Effects on Glucose Consumption in 3T3-L1 Adipocytes
TLDR
The results showed that 2-hydroxy-1-methoxyaporphine and pronuciferine increased the glucose consumption significantly as rosiglitazone did and the effects of four separated aporphine alkaloids on insulin-stimulated glucose consumption were examined.
Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus
TLDR
A comprehensive functional characterization of alkaloid biosynthetic enzymes using both in vitro and in vivo methods is required to advance limited knowledge of BIA metabolism in the sacred lotus.
Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity
TLDR
Overall, methanol extract of N. nucifera petals showed better activity than successive water extract, and showed evident agonist and antagonist activity towards 5-HT2C and CNR2 receptors, respectively.
BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells
TLDR
Blood–brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells, and good permeability of asimilobine and N-methylasimilobines was confirmed using an in vitro BBB model.
Analysis of Isoquinoline Alkaloid Composition and Wound-Induced Variation in Nelumbo Using HPLC-MS/MS.
TLDR
Wide variation of alkaloid accumulation in lamina and embryo was observed among screened genotypes, and mechanical wounding was shown to induce significant accumulation of specific alkaloids in lotus leaves.
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