Alkaline serine protease produced by Streptomyces sp. degrades PrP(Sc).

  title={Alkaline serine protease produced by Streptomyces sp. degrades PrP(Sc).},
  author={Zhao Hui and Hiroyasu Doi and Hiroaki Kanouchi and Yuichi Matsuura and Shiro Mohri and Yoshiaki Nonomura and Tatsuzo Oka},
  journal={Biochemical and biophysical research communications},
  volume={321 1},
A PrP(Sc)-degrading enzyme was isolated from the culture medium of Streptomyces sp. using perchloric acid-soluble protein (PSP) as a substrate. The media of 500 microbial species were screened to obtain the PSP-degrading enzyme. The medium containing the protease secreted from strain 99-GP-2D-5 showed the highest PSP-degrading activity. Strain 99-GP-2D-5 was assigned as the genus Streptomyces by its morphological and chemotaxonomic characteristics. When scrapie prion was used as the substrate… CONTINUE READING


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