Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.

@article{Heemskerk2009AlkalinePT,
  title={Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.},
  author={Suzanne Heemskerk and Rosalinde Masereeuw and Olof Moesker and Martijn P. W. J. M. Bouw and Johannes G Van der Hoeven and Wilbert H. M. Peters and Frans G. M. Russel and Peter Pickkers},
  journal={Critical care medicine},
  year={2009},
  volume={37 2},
  pages={417-23, e1}
}
OBJECTIVE Alkaline phosphatase (AP) attenuates inflammatory responses by lipopolysaccharide detoxification and may prevent organ damage during sepsis. To investigate the effect of AP in patients with severe sepsis or septic shock on acute kidney injury. DESIGN AND SETTING A multicenter double-blind, randomized, placebo-controlled phase IIa study (2:1 ratio). PATIENTS Thirty-six intensive care unit patients (20 men/16 women, mean age 58 +/- 3 years) with a proven or suspected Gram-negative… CONTINUE READING

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