Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.

  title={Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.},
  author={Suzanne Heemskerk and Rosalinde Masereeuw and Olof Moesker and Martijn P. W. J. M. Bouw and Johannes G Van der Hoeven and Wilbert H. M. Peters and Frans G. M. Russel and Peter Pickkers},
  journal={Critical care medicine},
  volume={37 2},
  pages={417-23, e1}
OBJECTIVE Alkaline phosphatase (AP) attenuates inflammatory responses by lipopolysaccharide detoxification and may prevent organ damage during sepsis. To investigate the effect of AP in patients with severe sepsis or septic shock on acute kidney injury. DESIGN AND SETTING A multicenter double-blind, randomized, placebo-controlled phase IIa study (2:1 ratio). PATIENTS Thirty-six intensive care unit patients (20 men/16 women, mean age 58 +/- 3 years) with a proven or suspected Gram-negative… CONTINUE READING


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Publications referenced by this paper.
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Up-regulation of renal iNOS during human endotoxemia and sepsis is associated with proximal tubule injury

S Heemskerk, P Pickkers, MP Bouw
Clin J Am Soc Nephrol • 2006
View 5 Excerpts
Highly Influenced

Acute renal failure and sepsis.

The New England journal of medicine • 2004
View 2 Excerpts

Clinical characteristics of patients developing ARF due to sepsis/systemic inflammatory response syndrome: results of a prospective study.

American journal of kidney diseases : the official journal of the National Kidney Foundation • 2004
View 1 Excerpt

Cardiovascular and renal control in NOS-deficient mouse models.

American journal of physiology. Regulatory, integrative and comparative physiology • 2003
View 3 Excerpts

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