Alkaline phosphatase enzyme-induced biomineralization of chitosan scaffolds with enhanced osteogenesis for bone tissue engineering

@article{Li2019AlkalinePE,
  title={Alkaline phosphatase enzyme-induced biomineralization of chitosan scaffolds with enhanced osteogenesis for bone tissue engineering},
  author={N. Li and L. Zhou and Weilong Xie and Deyi Zeng and Daqian Cai and H. Wang and Changren Zhou and J. Wang and L. Li},
  journal={Chemical Engineering Journal},
  year={2019},
  volume={371},
  pages={618-630}
}
Abstract To increase uniform deposition of nano-hydroxyapatite (n-HAP) in porous chitosan (CS) scaffolds, an alkaline phosphatase (ALP) enzyme-induced biomineralization method was developed. The results showed that s-glycerol phosphate calcium (s-GPC) could enter the scaffolds slowly through dialysis, be further decomposed to calcium and phosphate ions by preexisting ALP inside the scaffolds, and finally be transformed into n-HAP after aging for certain amount of time. The XRD and FT-IR results… Expand
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