AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation.

@article{Ougland2004AlkBRT,
  title={AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation.},
  author={Rune Ougland and Chun-mei Zhang and Aivar Liiv and Rune Forstr\om Johansen and Erling Seeberg and Ya-Ming Hou and Jaanus Remme and P{\aa}l \O Falnes},
  journal={Molecular cell},
  year={2004},
  volume={16 1},
  pages={107-16}
}
Deleterious 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions are introduced into nucleic acids by methylating agents. It was recently demonstrated that the E. coli AlkB protein and a human homolog, hABH3, can demethylate these lesions both in DNA and RNA. To elucidate the biological significance of the RNA repair, we have tested whether such repair can rescue the function of chemically methylated RNA. We demonstrate that a methylation-induced block in translation of an mRNA can be… CONTINUE READING
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