Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages

  title={Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages},
  author={T. Payne-Ferreira and P. Yelick},
  journal={Developmental Dynamics},
  • T. Payne-Ferreira, P. Yelick
  • Published 2003
  • Medicine, Biology
  • Developmental Dynamics
  • The type I TGFβ family member receptor alk8 acts in bone morphogenetic protein (BMP) signaling pathways to establish dorsoventral patterning in the early zebrafish embryo. Here, we present evidence that alk8 is required for neural crest cell (NCC) formation and that alk8 signaling gradients direct the proper patterning of premigratory NCCs. We extend our previous functional studies of alk8 to demonstrate that ectopic expression of constitutively active and dominant negative Alk8, consistently… CONTINUE READING
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