Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.

@article{MahulMellier2008AlixAA,
  title={Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.},
  author={Anne-Laure Mahul-Mellier and Flavie Strappazzon and Anne Petiot and Christine Chatellard-Causse and Sakina Torch and B{\'e}atrice Blot and Kimberley Freeman and Loriane Kuhn and J{\'e}r{\^o}me Garin and J. Verna and Sandrine Fraboulet and R{\'e}my Sadoul},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 50},
  pages={34954-65}
}
Alix/AIP1 regulates cell death in a way involving interactions with the calcium-binding protein ALG-2 and with proteins of ESCRT (endosomal sorting complex required for transport). Using mass spectrometry we identified caspase-8 among proteins co-immunoprecipitating with Alix in dying neurons. We next demonstrated that Alix and ALG-2 interact with pro-caspase-8 and that Alix forms a complex with the TNFalpha receptor-1 (TNF-R1), depending on its capacity to bind ESCRT proteins. Thus, Alix and… CONTINUE READING