Aliskiren/Hydrochlorothiazide Combination

@article{Baldwin2012AliskirenHydrochlorothiazideC,
  title={Aliskiren/Hydrochlorothiazide Combination},
  author={Claudine M. Baldwin and Greg L. Plosker},
  journal={Drugs},
  year={2012},
  volume={69},
  pages={833-841}
}
Abstract▲ Aliskiren/hydrochlorothiazide is a single-pill combination of the first in the new class of non-peptide direct renin inhibitors (aliskiren) and a thiazide diuretic (hydrochlorothiazide [HCTZ]) that achieves blood pressure (BP) reductions greater than those seen with either component alone.▲ In double-blind, 8-week clinical trials, aliskiren and HCTZ (as a combination of the individual components or as single-pill combinations) reduced mean sitting systolic and diastolic BP from… 
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References

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Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders
TLDR
Aliskiren/HCT single-pill combinations provide clinically significant additional BP reductions and improved BP control rates over aliskiren alone in patients who are non-responsive to aliskirens monotherapy.
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
TLDR
Aliskiren monotherapy demonstrated significant BP lowering, and its effect was considerably greater when combined with HCTZ, and Renin inhibition with aliskiren neutralized the compensatory rise in PRA induced by HCTz.
Irbesartan/Hydrochlorothiazide
TLDR
The proportion of patients with severe hypertension achieving controlled BP of <140/ 90 mmHg was significantly greater at all timepoints of the trial compared with irbesartan monotherapy, and Irbesartsartan/HCTZ combination therapy had a similar tolerability profile to irbsartan and HCTZ monotherapy.
Antihypertensive efficacy and tolerability of aliskiren/hydrochlorothiazide (HCT) single-pill combinations in patients who are non-responsive to HCT 25 mg alone.
TLDR
Aliskiren/HCT SPCs provide clinically significant BP reductions and improved BP control rates in patients who are non-responsive to HCT 25 mg monotherapy and showed similar tolerability to H CT alone and a numerically lower incidence of hypokalemia.
Antihypertensive efficacy and tolerability of aliskiren/hydrochlorothiazide (HCT) single-pill combinations in patients who are non-responsive to HCT 25 mg alone*
TLDR
Aliskiren/HCT SPCs provide clinically significant BP reductions and improved BP control rates in patients who are non-responsive to HCT 25 mg monotherapy.
Telmisartan/Hydrochlorothiazide
TLDR
In clinical trials of up to 4 years, including elderly patients, telmisartan/HCTZ had similar tolerability to placebo, with few reports of hypokalaemia and most adverse events were mild to moderate.
Aliskiren: a review of its use in the management of hypertension.
TLDR
By offering a new approach to the blockade of the RAS, aliskiren provides a useful addition to the therapeutic options available to treat patients with mild to moderate hypertension.
Direct Renin Inhibition With Aliskiren in Obese Patients With Arterial Hypertension
TLDR
Combined treatment with aliskiren is a highly effective and well-tolerated therapeutic option for obese patients with hypertension who fail to achieve blood pressure control with first-line thiazide diuretic treatment.
Effects of Aliskiren, a Direct Renin Inhibitor, on Cardiac Repolarization and Conduction in Healthy Subjects
TLDR
Aliskiren at the highest approved dose (300 mg) and a 4‐fold higher dose had no effect on cardiac repolarization or conduction in healthy volunteers.
Aliskiren for Renin Inhibition: A New Class of Antihypertensives
TLDR
Aliskiren appears to be a safe and effective treatment option in mild-to-moderate hypertension, and although long-term outcome data have not been published, aliskiren is a promising option for RAS inhibition.
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