Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients.

@article{Gradman2005AliskirenAN,
  title={Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients.},
  author={Alan H. Gradman and Roland E Schmieder and Robert L Lins and Juerg Nussberger and Yanntong Chiang and Martin P Bedigian},
  journal={Circulation},
  year={2005},
  volume={111 8},
  pages={1012-8}
}
BACKGROUND Stopping the detrimental effects of the renin-angiotensin system at the most upstream point of the cascade offers theoretical advantages for cardiovascular protection. This study compares the antihypertensive efficacy and safety of the novel oral renin inhibitor aliskiren with placebo and an active comparator. METHODS AND RESULTS The study was a randomized, multicenter, double-blind, placebo-controlled, active-comparator 8-week trial in patients with mild-to-moderate hypertension… CONTINUE READING
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