Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure.

@article{McMurray2016AliskirenEO,
  title={Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure.},
  author={John J V McMurray and Henry Krum and William T. Abraham and Kenneth Dickstein and Lars Valeur K{\o}ber and Akshay S. Desai and Scott Solomon and Nicola Greenlaw and Mohammad Liaquat Ali and Yanntong Chiang and Qing Shao and Georgia Tarnesby and Barry M. Massie},
  journal={The New England journal of medicine},
  year={2016},
  volume={374 16},
  pages={
          1521-32
        }
}
BACKGROUND Among patients with chronic heart failure, angiotensin-converting-enzyme (ACE) inhibitors reduce mortality and hospitalization, but the role of a renin inhibitor in such patients is unknown. We compared the ACE inhibitor enalapril with the renin inhibitor aliskiren (to test superiority or at least noninferiority) and with the combination of the two treatments (to test superiority) in patients with heart failure and a reduced ejection fraction. METHODS After a single-blind run-in… CONTINUE READING
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