Aliphatic polyesters. I. The degradation of poly(ϵ‐caprolactone) in vivo

@inproceedings{Pitt1981AliphaticPI,
  title={Aliphatic polyesters. I. The degradation of poly(ϵ‐caprolactone) in vivo},
  author={Colin G. Pitt and Fred I. Chasalow and Y. M. Hibionada and Denise M. Klimas and Anton Schindler},
  year={1981}
}
The degradation of poly(ϵ-caprolactone) in rabbits, rats, and water was studied by measurement of changes in intrinsic viscosity, molecular weight, crystallinity, Young's modulus, and weight. Degradation proceeds by nonenzymatic random hydrolytic cleavage of ester linkages. The process is autocatalytic, and the kinetic relationship Mn/Mno = exp(–kt) is observed until the Mn has decreased to approximately 5000. Significant weight loss is not observed until this point but, once initiated, the… CONTINUE READING

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