Alinidine reduces the incidence of ischemic ventricular fibrillation in a conscious canine model, a protective effect antagonized by overdrive atrial pacing.

Abstract

The antiarrhythmic and antifibrillatory effects of the specific bradycardic agent alinidine were evaluated in a conscious canine model of myocardial infarction and sudden death, and by determination of ventricular fibrillation thresholds (VFT) in anesthetized dogs. Programmed electrical stimulation (PES) was performed in conscious animals, 3-5 days after a… (More)

Topics

Cite this paper

@article{Uprichard1989AlinidineRT, title={Alinidine reduces the incidence of ischemic ventricular fibrillation in a conscious canine model, a protective effect antagonized by overdrive atrial pacing.}, author={Andrew C.G. Uprichard and Liguo Chi and Joseph J. Lynch and Edward M. Driscoll and John William Frye and Benedict Robert Lucchesi}, journal={Journal of cardiovascular pharmacology}, year={1989}, volume={14 3}, pages={475-82} }