Alignment of Optical Maps

  title={Alignment of Optical Maps},
  author={Anton Valouev and Lei Li and Yu-Chi Liu and David C. Schwartz and Yi Yang and Yu Zhang and Michael S. Waterman},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={13 2},
We introduce a new scoring method for calculation of alignments of optical maps. Missing cuts, false cuts, and sizing errors present in optical maps are addressed by our alignment score through calculation of corresponding likelihoods. The size error model is derived through the application of Central Limit Theorem and validated by residual plots collected from real data. Missing cuts and false cuts are modeled as Bernoulli and Poisson events, respectively, as suggested by previous studies… CONTINUE READING
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