AlignGraph: algorithm for secondary de novo genome assembly guided by closely related references

@inproceedings{Bao2014AlignGraphAF,
  title={AlignGraph: algorithm for secondary de novo genome assembly guided by closely related references},
  author={Ergude Bao and Tao Jiang and Thomas Girke},
  booktitle={Bioinformatics},
  year={2014}
}
MOTIVATION De novo assemblies of genomes remain one of the most challenging applications in next-generation sequencing. Usually, their results are incomplete and fragmented into hundreds of contigs. Repeats in genomes and sequencing errors are the main reasons for these complications. With the rapidly growing number of sequenced genomes, it is now feasible to improve assemblies by guiding them with genomes from related species. RESULTS Here we introduce AlignGraph, an algorithm for extending… CONTINUE READING

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