Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines.

@article{Waljee2010AlgorithmsOM,
  title={Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines.},
  author={Akbar K Waljee and Joel C Joyce and Sijian Wang and Aditi Saxena and Margaret Hart and Ji Zhu and Peter D. R. Higgins},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2010},
  volume={8 2},
  pages={143-50}
}
BACKGROUND & AIMS Levels of the thiopurine metabolites 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine commonly are monitored during thiopurine therapy for inflammatory bowel disease despite this test's high cost and poor prediction of clinical response (sensitivity, 62%; specificity, 72%). We investigated whether patterns in common laboratory parameters might be used to identify appropriate immunologic responses to thiopurine and whether they are more accurate than measurements of… CONTINUE READING