Algorithms and software for support of gene identification experiments

  title={Algorithms and software for support of gene identification experiments},
  author={Sing-Hoi Sze and Mikhail A. Roytberg and Mikhail S. Gelfand and Andrey A. Mironov and Tatiana V. Astakhova and Pavel A. Pevzner},
  volume={14 1},
MOTIVATION Gene annotation is the final goal of gene prediction algorithms. However, these algorithms frequently make mistakes and therefore the use of gene predictions for sequence annotation is hardly possible. As a result, biologists are forced to conduct time-consuming gene identification experiments by designing appropriate PCR primers to test cDNA libraries or applying RT-PCR, exon trapping/amplification, or other techniques. This process frequently amounts to 'guessing' PCR primers on… CONTINUE READING
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