Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism

@article{Kinkead2006AlgorithmicallyDP,
  title={Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism},
  author={Becky Kinkead and Karen A. Selz and Michael J. Owens and Arnold J. Mandell},
  journal={Journal of Neuroscience Methods},
  year={2006},
  volume={151},
  pages={68-81}
}
This study exemplifies the use of three ADHD-relevant methodological innovations. (1) The use of novel, patented, computational peptide design techniques to generate peptides targeting the extra-cellular and para-transmembrane amino acid loops of the putatively ADHD-involved, D(2) dopamine receptor, D(2)DAR; (2) experimental evidence that these peptides in L-amino acid/ortho ordered or D-amino acid/reverse ordered (retro-inverso), D(2)DAR, hydrophobic eigenmode matched forms, evoked positive… CONTINUE READING

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