Algorithmic approach to quantifying the hydrophobic force contribution in protein folding

  title={Algorithmic approach to quantifying the hydrophobic force contribution in protein folding},
  author={Rolf Backofen and Sebastian Will and Peter Clote},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
Though the electrostatic, ionic, van der Waals, Lennard-Jones, hydrogen bonding, and other forces play an important role in the energy function minimized at a protein's native state, it is widely believed that the hydrophobic force is the dominant term in protein folding. Here we attempt to quantify the extent to which the hydrophobic force determines the positions of the backbone alpha-carbon atoms in PDB data, by applying Monte-Carlo and genetic algorithms to determine the predicted… CONTINUE READING


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