Algorithmic approach to quantifying the hydrophobic force contribution in protein folding

@article{Backofen1999AlgorithmicAT,
  title={Algorithmic approach to quantifying the hydrophobic force contribution in protein folding},
  author={Rolf Backofen and Sebastian Will and Peter Clote},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={1999},
  pages={95-106}
}
Though the electrostatic, ionic, van der Waals, Lennard-Jones, hydrogen bonding, and other forces play an important role in the energy function minimized at a protein's native state, it is widely believed that the hydrophobic force is the dominant term in protein folding. Here we attempt to quantify the extent to which the hydrophobic force determines the positions of the backbone alpha-carbon atoms in PDB data, by applying Monte-Carlo and genetic algorithms to determine the predicted… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 31 references

Personal communication, Jan

W. Gilbert
1999
View 1 Excerpt

Protein folding in the hydrophobihydrophili ( HP ) model is NPomplete

T. Leighton.
1998

Toward a resolution of the introns early/late debate: only phase zero introns are correlated with the structure of ancient proteins.

Proceedings of the National Academy of Sciences of the United States of America • 1998
View 1 Excerpt

and K

H. S. Cha
Dill. Personal communication, • 1998

Predi tion of the quaternary stru ture of oiled oils . Appli ationto mutants of the GCN 4 leu ine zipper

A. Kolinski, J. Skolni k.
Journal of Mole ular Biology • 1997

Prediction of the quaternary structure of coiled coils . Application to mutants of the GCN 4 leucine zipper

A. Kolinski M. Vieth, J. Skolnick
Biophys . J . • 1997

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