Algorithm for cellular reprogramming

@article{Ronquist2017AlgorithmFC,
  title={Algorithm for cellular reprogramming},
  author={Scott Ronquist and Geoff Patterson and Lindsey A. Muir and Stephen Lindsly and Haiming Chen and Markus A. Brown and Max S. Wicha and Anthony M. Bloch and Roger W. Brockett and Indika Rajapakse},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114},
  pages={11832 - 11837}
}
Significance Reprogramming the human genome toward any desirable state is within reach; application of select transcription factors drives cell types toward different lineages in many settings. We introduce the concept of data-guided control in building a universal algorithm for directly reprogramming any human cell type into any other type. Our algorithm is based on time series genome transcription and architecture data and known regulatory activities of transcription factors, with natural… 

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