• Corpus ID: 247594015

Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity

@inproceedings{Zhang2020AlgorithmFO,
  title={Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity},
  author={He Zhang and Liang Zhang and Ang Lin and Congcong Xu and Ziyu Li and Kaibo Liu and Boxiang Liu and Xiao-Tu Ma and Fanfan Zhao and Weiguo Yao and Hangwen Li and David H. Mathews and Yujian Zhang and Liang Huang},
  year={2020}
}
Messenger RNA (mRNA) vaccines are being used for COVID-19, but still suffer from the critical issue of mRNA instability and degradation, which is a major obstacle in the storage, distribution, and efficacy of the vaccine. Previous work showed that optimizing secondary structure stability lengthens mRNA half-life, which, together with optimal codons, increases protein expression. Therefore, a principled mRNA design algorithm must optimize both structural stability and codon usage to improve mRNA… 

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LinAliFold and CentroidLinAliFold: Fast RNA consensus secondary structure prediction for aligned sequences using beam search methods
TLDR
LinAliFold and CentroidLinAli-Fold are developed, fast RNA consensus secondary structure prediction tools based on minimum free energy and maximum expected accuracy principles, respectively, and it is confirmed that the predicted consensussecondary structure of coronaviruses was consistent with the experimental results.