Alginate modification improves long-term survival and function of transplanted encapsulated islets.

@article{Mallett2009AlginateMI,
  title={Alginate modification improves long-term survival and function of transplanted encapsulated islets.},
  author={Aaron G Mallett and Gregory S. Korbutt},
  journal={Tissue engineering. Part A},
  year={2009},
  volume={15 6},
  pages={1301-9}
}
Despite recent successes in islet transplantation, current immunosuppression protocols required to prevent graft rejection are not suitable for all patients. As a consequence, microencapsulation of islets in alginate has been proposed to protect islets from immune-mediated destruction. Success has been limited, however, due largely to problems with alginate biocompatibility and insufficient immunoprotection by the capsule. The aim of this study was to develop a purified, highly biocompatible… CONTINUE READING

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Asso - ciation between macrophage activation and function of microencapsulated rat islets

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