Alginate-diltiazem hydrochloride beads: optimization of formulation factors, in vitro and in vivo availability.

  title={Alginate-diltiazem hydrochloride beads: optimization of formulation factors, in vitro and in vivo availability.},
  author={Amal Hassan El-Kamel and Omaimah M N Al-Gohary and Ehab A Hosny},
  journal={Journal of microencapsulation},
  volume={20 2},
Alginate beads containing diltiazem hydrochloride (DTZ) were prepared by the ionotropic gelation method. The effects of various factors (alginate concentration, additives type, calcium chloride concentration and curing time) on the efficiency of drug loading were investigated. The formulation containing a mixture of 0.8% methylcellulose (MC) and 4% alginate cured in 2% calcium chloride for 6 h was chosen as the best formula regarding the loading efficiency. The release rate of DTZ from various… CONTINUE READING


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