Alginate-diltiazem hydrochloride beads: optimization of formulation factors, in vitro and in vivo availability.

@article{ElKamel2003AlginatediltiazemHB,
  title={Alginate-diltiazem hydrochloride beads: optimization of formulation factors, in vitro and in vivo availability.},
  author={Amal Hassan El-Kamel and Omaimah M N Al-Gohary and Ehab A Hosny},
  journal={Journal of microencapsulation},
  year={2003},
  volume={20 2},
  pages={211-25}
}
Alginate beads containing diltiazem hydrochloride (DTZ) were prepared by the ionotropic gelation method. The effects of various factors (alginate concentration, additives type, calcium chloride concentration and curing time) on the efficiency of drug loading were investigated. The formulation containing a mixture of 0.8% methylcellulose (MC) and 4% alginate cured in 2% calcium chloride for 6 h was chosen as the best formula regarding the loading efficiency. The release rate of DTZ from various… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Gel and jellies

J. Swarbrick, J. C. Boylan
In Encyclopedia of pharmaceutical technology, • 1992
View 4 Excerpts
Highly Influenced

Alginate controlled release formulations of metribuzin

A. B. Pepperman, C. W. Kuan, C. McCombs
Journal of Controlled Release, • 1991
View 5 Excerpts
Highly Influenced

intestinal delivery of nitrofurantoin

T. Imai, C. Kawasaki, T. Nishiyama, M. Otagiri
Journal of Microencapsulation, • 2000
View 1 Excerpt

Formulation and investigation of nicardipine HCl-alginate gel beads with factorial design-based studies.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 1998
View 2 Excerpts

Similar Papers

Loading similar papers…