Alginate/PEI/DNA polyplexes: a new gene delivery system.


AIM To avoid the limitation of the use of cationic polyethlenimine (PEI)-complexed plasmid DNA use for in vitro or in vivo gene delivery due to its cytotoxicity and lower efficiency in the presence of serum. METHODS A polyplex with decreased positive charge on the complex surface was designed. The PEI/DNA (PD) complexes coated with an anionic… (More)


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@article{Jiang2006AlginatePEIDNAPA, title={Alginate/PEI/DNA polyplexes: a new gene delivery system.}, author={Ge Jiang and Sang-Hyun Min and Mi Na Kim and Dong-Chul Lee and Mi-Jung Lim and Young-Il Yeom}, journal={Yao xue xue bao = Acta pharmaceutica Sinica}, year={2006}, volume={41 5}, pages={439-45} }