Alginate Microencapsulated Hepatocytes Optimised for Transplantation in Acute Liver Failure

@inproceedings{Jitraruch2014AlginateMH,
  title={Alginate Microencapsulated Hepatocytes Optimised for Transplantation in Acute Liver Failure},
  author={Suttiruk Jitraruch and Anil Dhawan and Robin D. Hughes and C{\'e}line Filippi and Daniel Soong and Christina Philippeos and Sharon C. Lehec and N. Heaton and Maria Serena Longhi and Ragai R. Mitry},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND AND AIM Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive option for the management of acute liver failure (ALF) providing short-term support to allow native liver regeneration. The main aim of this study was to establish an optimised protocol for production of alginate-encapsulated human hepatocytes and evaluate their suitability for clinical use. METHODS Human hepatocyte microbeads (HMBs) were prepared using sterile GMP grade… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.

  • Methods in molecular biology
  • 2017
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Cell-based liver therapies: past, present and future.

  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2018

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Reduction of inflammatory reaction in the use of purified alginate microcapsules.

  • Journal of biomaterials science. Polymer edition
  • 2013
VIEW 1 EXCERPT

of microencapsulated primary or immortalized xenogeneic hepatocytes

A Sgroi, G Mai, P Morel, RM Baertschiger, C Gonelle-Gispert
  • 2011

Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation.

  • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2010
VIEW 1 EXCERPT