Alerting and tuning the immune response by extracellular nucleotides.

  title={Alerting and tuning the immune response by extracellular nucleotides.},
  author={Andrea la Sala and Davide Ferrari and Francesco Di Virgilio and Marco Idzko and Johannes Norgauer and Giampiero Girolomoni},
  journal={Journal of leukocyte biology},
  volume={73 3},
The interplay between pro- and anti-inflammatory mechanisms during inflammatory and immune responses is critical for avoiding excessive tissue damage. Extracellular nucleotides (e.g., adenosine 5'-triphosphate) may represent constitutive signals that can alert the immune system of abnormal cell death. Relatively high doses of nucleotides induce rapid release of proinflammatory mediators and favor pathogen killing. However, recent findings on antigen presenting cells, particularly dendritic… CONTINUE READING

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