Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV.

@article{Mccomsey2007AlendronateWC,
  title={Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV.},
  author={Grace A. Mccomsey and M A Kendall and Pablo Tebas and Susan S Swindells and Evelyn Hogg and Beverly Alston-Smith and Carol Suckow and Geetha Gopalakrishnan and Constance Benson and David A Wohl},
  journal={AIDS},
  year={2007},
  volume={21 18},
  pages={2473-82}
}
BACKGROUND Decreased bone mineral density (BMD) is prevalent in HIV-infected patients. Bisphosphonates are currently the mainstay of treatment for postmenopausal and male osteoporosis in HIV-uninfected individuals; however, their efficacy and safety in HIV-infected patients remains unclear. METHODS In this prospective, randomized, placebo-controlled multicenter trial, we studied the effectiveness of calcium and vitamin D supplementation with or without alendronate in improving BMD in HIV… CONTINUE READING

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