Alendronate-loaded microparticles for improvement of intestinal cellular absorption.

  title={Alendronate-loaded microparticles for improvement of intestinal cellular absorption.},
  author={Jong-Suep Baek and Hae-Hyun Kwon and Ji-Sook Hwang and Ha-Chang Sung and J S Lee and Sang-Chul Shin and Young Ran Kim and Cheong-Weon Cho},
  journal={Journal of drug targeting},
  volume={19 1},
This study examined a novel alendronate formulation that was developed to overcome the shortcomings of alendronate, such as its low bioavailability and gastric adverse effects. Alendronate microparticles were prepared using mucoadhesive polymers such as chitosan for improving the intestinal cellular absorption of alendronate and also using a gastric-resistant polymer such as Eudragit L100-55 for reducing the gastric inflammation of alendronate. Alendronate microparticles including chitosan… CONTINUE READING