Alendronate in the treatment of low bone mass in steroid-treated boys with Duchennes muscular dystrophy.

@article{Hawker2005AlendronateIT,
  title={Alendronate in the treatment of low bone mass in steroid-treated boys with Duchennes muscular dystrophy.},
  author={Gillian Hawker and Rowena Ridout and Vivien A Harris and Cheryl Chase and Lynda J Fielding and W. Douglas Biggar},
  journal={Archives of physical medicine and rehabilitation},
  year={2005},
  volume={86 2},
  pages={284-8}
}
OBJECTIVE To examine alendronates side-effect profile and effect on bone mineral density (BMD) in deflazacort-treated boys with Duchennes muscular dystrophy (DMD) and low BMD. DESIGN Before-after trial. SETTING Neuromuscular clinic at a children's hospital in Canada between 1999 and 2000. PARTICIPANTS All consenting boys with DMD who had z scores less than -1.00 (spine and/or total body) and in whom BMD testing was feasible. INTERVENTION Boys received .08 mg.kg(-1) .d(-1) of alendronate… CONTINUE READING

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