Alendronate as a robust anchor for ceria nanoparticle surface coating: facile binding and improved biological properties

@inproceedings{Yang2014AlendronateAA,
  title={Alendronate as a robust anchor for ceria nanoparticle surface coating: facile binding and improved biological properties},
  author={Zhangyou Yang and Sheng-Lin Luo and Hong Li and Shiwu Dong and Jian Yun He and Hong Jiang and Rong Li and Xiaochao Yang},
  year={2014}
}
The bisphosphonate group of alendronate was found to possess high binding affinity to ceria nanoparticles (CNPs). Using alendronate as an anchor, functional molecules could be easily grafted onto CNPs leading to enhanced enzyme mimetic activity, reduced cytotoxicity, improved stability, prolonged blood circulation, and decreased liver and especially spleen accumulation of the nanoparticles. 

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