Alendronate Reduces Adhesion of Human Osteoclast-like Cells to Bone and Bone Protein-Coated Surfaces

@article{Colucci1998AlendronateRA,
  title={Alendronate Reduces Adhesion of Human Osteoclast-like Cells to Bone and Bone Protein-Coated Surfaces},
  author={S. Colucci and V. Minielli and G. Zambonin and Nunzio Cirulli and Giorgio Mori and Massimo Serra and Vittorio Patella and A. Zambonin Zallone and Maria Grano},
  journal={Calcified Tissue International},
  year={1998},
  volume={63},
  pages={230-235}
}
Bisphosphonates (BPs) are potent inhibitors of bone resorption and are therapeutically effective in disease of increased bone turnover, but their mechanism(s) of action remain to be elucidated. Using as experimental model human osteoclast-like cell lines derived from giant cell tumors of bone, extensively characterized for their osteoclast features, we investigated the adhesive properties of osteoclasts on bone slices and on different proteins of the extracellular matrix in the presence of BPs… CONTINUE READING

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