Aldosterone up-regulates MMP-9 and MMP-9/NGAL expression in human neutrophils through p38, ERK1/2 and PI3K pathways.

Abstract

Aldosterone and mineralocorticoid receptors are important regulators of inflammation. During this process, chemokines and extracellular matrix degradation by matrix metalloproteases, such as MMP-9, help leukocytes reaching swiftly and infiltrating the injured tissue, two processes essential for tissue repair. Leukocytes, such as neutrophils, are a rich… (More)
DOI: 10.1016/j.yexcr.2014.11.004

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@article{Gilet2015AldosteroneUM, title={Aldosterone up-regulates MMP-9 and MMP-9/NGAL expression in human neutrophils through p38, ERK1/2 and PI3K pathways.}, author={Alexandre Gilet and Feng Zou and Meriem Boumenir and J P Frippiat and Simon Nigel Thornton and Patrick J. Lacolley and Armelle Ropars}, journal={Experimental cell research}, year={2015}, volume={331 1}, pages={152-63} }