Aldosterone synthesis by adrenal mitochondria. II. The effect of citric acid cycle intermediates; identification of the soluble stimulatory factor as fumarase.

Abstract

The formation of aldosterone from corticosterone by the mitochondrial fraction of adrenal homogenates requires the presence of a citric acid cycle intermediate. The most effective intermediate is malate. The stimulation by the soluble fraction of mitochondrial aldosterone formation in the presence of fumarate, reported previously, is the result of conversion of the fumarate to malate by fumarase present in the soluble fraction.

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Cite this paper

@article{Tallan1967AldosteroneSB, title={Aldosterone synthesis by adrenal mitochondria. II. The effect of citric acid cycle intermediates; identification of the soluble stimulatory factor as fumarase.}, author={Harris H Tallan and Stacy Psychoyos and Paul Greengard}, journal={The Journal of biological chemistry}, year={1967}, volume={242 8}, pages={1912-4} }