Aldosterone-sensitive neurons in the rat central nervous system.

  title={Aldosterone-sensitive neurons in the rat central nervous system.},
  author={Joel C Geerling and Mitsuhiro Kawata and Arthur D. Loewy},
  journal={The Journal of comparative neurology},
  volume={494 3},
The purpose of this study was to identify brain sites that may be sensitive to the adrenal steroid aldosterone. After a survey of the entire brain for mineralocorticoid receptor (MR) immunoreactivity, we discovered unique clusters of dense nuclear and perinuclear MR in a restricted distribution within the nucleus of the solitary tract (NTS). These same cells were found to contain the glucocorticoid-inactivating enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), a signature of… CONTINUE READING
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