Aldosterone-sensitive neurons in the nucleus of the solitary: efferent projections.

  title={Aldosterone-sensitive neurons in the nucleus of the solitary: efferent projections.},
  author={Joel C Geerling and Arthur D. Loewy},
  journal={The Journal of comparative neurology},
  volume={498 3},
The nucleus of the solitary tract (NTS) contains a subpopulation of neurons that express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), which makes them uniquely sensitive to aldosterone. These neurons may drive sodium appetite, which is enhanced by aldosterone. Anterograde and retrograde neural tracing techniques were used to reveal the efferent projections of the HSD2 neurons in the rat. First, the anterograde tracer Phaseolus vulgaris leucoagglutinin was used to label axonal… CONTINUE READING


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