Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment.

@article{Geerling2006AldosteronesensitiveNN,
  title={Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment.},
  author={Joel C Geerling and Arthur D. Loewy},
  journal={Brain research},
  year={2006},
  volume={1115 1},
  pages={54-64}
}
The nucleus of the solitary tract (NTS) contains a unique subpopulation of neurons that express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2). These neurons are mineralocorticoid-sensitive and are activated in association with salt appetite during sodium deficiency. In the absence of sodium deficiency, the HSD2 neurons and sodium appetite are both stimulated by chronic mineralocorticoid administration. After 7 days of treatment with deoxycorticosterone (2 mg/day), an increased… CONTINUE READING
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