Aldosterone receptors in A6 cells: physicochemical characterization and autoradiographic study.

@article{Claire1989AldosteroneRI,
  title={Aldosterone receptors in A6 cells: physicochemical characterization and autoradiographic study.},
  author={Maree Claire and B Machard and Marc Lomb{\`e}s and M E Oblin and J. P. Bonvalet and Nicolette Farman},
  journal={The American journal of physiology},
  year={1989},
  volume={257 4 Pt 1},
  pages={C665-77}
}
The A6 cell line is derived from the kidney of Xenopus laevis. Aldosterone increases sodium transport across A6 cell epithelia. In the present study, aldosterone binding characteristics were studied in A6 cell cytosol. Both type I (mineralocorticoid) and type II (glucocorticoid) receptors are present in the cytosolic fraction of these cells. Aldosterone and corticosterone had a high affinity for type I sites (Kd = 1.25 and 0.16 nM, respectively) and a lower affinity for type II sites (Kd = 39… CONTINUE READING

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