Aldosterone promotes proximal tubular cell apoptosis: role of oxidative stress.

@article{Patni2007AldosteronePP,
  title={Aldosterone promotes proximal tubular cell apoptosis: role of oxidative stress.},
  author={Hitesh Patni and Jayant Thomas Mathew and Liming Luan and Nicholas Franki and Praveen N. Chander and Pravin C. Singhal},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 4},
  pages={
          F1065-71
        }
}
Aldosterone has attracted significant consideration for its role in the progression of renal injury. Since apoptotic cell loss contributes to the deterioration of renal function, we examined the effect of aldosterone on tubular cell apoptosis. To determine dose and time course effect, human renal proximal tubular (HK2) cells were treated with aldosterone at different doses and for variable time periods followed by evaluation for apoptosis. To determine the role of mineralocorticoid receptors… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

Aldosterone induces p21-regulated apoptosis via increased synthesis and secretion of tumour necrosis factor-α in human proximal tubular cells.

  • Clinical and experimental pharmacology & physiology
  • 2012
VIEW 3 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Aldosterone breakthrough does not alter central hemodynamics

  • Journal of the renin-angiotensin-aldosterone system : JRAAS
  • 2017

Aldosterone and TGF-β₁ synergistically increase PAI-1 expression in hepatic stellate cells of rats.

  • International journal of clinical and experimental pathology
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

High Calorie Diet and the Human Brain

  • Springer International Publishing
  • 2015

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Role of aldosterone in the remnant kidney model in the rat.

  • The Journal of clinical investigation
  • 1996
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Aldosterone and renal injury.

  • Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  • 2004
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…