Aldosterone promotes proximal tubular cell apoptosis: role of oxidative stress.

@article{Patni2007AldosteronePP,
  title={Aldosterone promotes proximal tubular cell apoptosis: role of oxidative stress.},
  author={Hitesh Patni and Jayant Thomas Mathew and Liming Luan and Nicholas Franki and Praveen N. Chander and Pravin C. Singhal},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 4},
  pages={
          F1065-71
        }
}
Aldosterone has attracted significant consideration for its role in the progression of renal injury. Since apoptotic cell loss contributes to the deterioration of renal function, we examined the effect of aldosterone on tubular cell apoptosis. To determine dose and time course effect, human renal proximal tubular (HK2) cells were treated with aldosterone at different doses and for variable time periods followed by evaluation for apoptosis. To determine the role of mineralocorticoid receptors… CONTINUE READING

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