Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes.

@article{Muto2007AldosteroneMI,
  title={Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes.},
  author={Takao Muto and Norihiro Ueda and Tobias Opthof and Tomoko Ohkusa and Kohzo Nagata and Shinsuke Suzuki and Yukiomi Tsuji and Mitsuru Horiba and Jong-Kook Lee and Haruo Honjo and Kaichiro Kamiya and Itsuo Kodama and Kenji Yasui},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 5},
  pages={H2710-8}
}
Mineralocorticoid receptor (MR) antagonists decrease the incidence of sudden cardiac death in patients with heart failure, as has been reported in two clinical trials (Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study). Aldosterone has been shown to increase the propensity to arrhythmias by changing the expression or function of various ion channels. In this study, we investigate the effect of aldosterone on the… CONTINUE READING

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